Nonalcoholic fatty liver disease can be divided into isolated fatty liver in which there is only accumulation of fat, and nonalcoholic steatohepatitis (NASH) in which there is fat, inflammation, and damage to liver cells.
Nonalcoholic fatty liver disease is considered a manifestation of the metabolic syndrome.
- The symptoms of nonalcoholic fatty liver disease are primarily those of the complications of cirrhosis in patients with NASH; isolated fatty liver infrequently causes symptoms and usually is discovered incidentally. The complications of cirrhosis include:
- The differentiation of isolated fatty liver from NASH usually requires a liver biopsy.
- The most promising treatments for nonalcoholic fatty liver disease are
- Several drugs have been studied in the treatment of NASH. There is little evidence that any drug is effective in slowing the disease progression of NASH.
- Many diseases are associated with NASH and are part of the metabolic syndrome. These diseases should be screened for and treated, for example, high blood pressure, dyslipidemia and diabetes.
- Isolated fatty liver rarely progresses to NASH or cirrhosis.
- Nonalcoholic fatty liver disease, including NASH affects young children as well.
- NASH will become the number one reason for liver transplantation unless effective and safe treatments are found.